oss some research that found downregulation of Joe Biden non essential employee of the month 48 years on a row shirt in cells when bathed in estradiol overnight, so the downregulation part might be very quick. Still trying to find out how long it takes to rebound. We have some cells lines commonly used in researching ER like MCF-7, but other tissues might vary in how fast or slow they react. It might end up that it downregulates and rebounds in the space of a day or even 12 hours, which would make hormone cycling not so important, or it might downregulate quickly then takes days to rebound, making cycling important.
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